Yamamura and Miyagawa Lab's research paper chosen as the Front Cover Art for New Journal of Chemistry, a journal of the Royal Society of Chemistry
Category：News｜Publishing : September 5, 2023
The research paper of the Yamamura and Miyagawa Lab, which was published in the scientific journal New Journal of Chemistry of the Royal Society of Chemistry (RSC), was highly evaluated and chosen as the Front Cover Art (Issue 23, June 21, 2023). The title of the paper is "Anti-bacterial β-cyclodextrin derivatives inspired by the anti-microbial peptide polymyxin in order to better understand the role of single hydrophobic chain tail in selective anti-bacterial activity." This is the result of joint research by Professor Hatsuo Yamamura (Department of Engineering (Life Science and Applied Chemistry)) and Associate Professor Atsushi Miyagawa (Department of Engineering (Life Science and Applied Chemistry)), Mr. Masashi Owaki, Ms. Kana Isshiki, and Ms. Yukari Ishihara(students of the Master's Course, at the time of research) as well as faculty members of Shujitsu University and Kobe Tokiwa University.
Professor Yamamura and Associate Professor Miyagawa have been working on research on antibacterial substances that fight pathogenic bacteria. The research demonstrated that properties enabling the elimination of bacteria without harming red blood cells can be provided to cyclic oligosaccharides cyclodextrins by adding a membrane-disrupting ability which affects the bacterial membrane, based on imitation of colistin, an antimicrobial peptide used for treatment of infectious deceases. The oligosaccharides also proved effective against multidrug-resistant pathogens, which are considered to be hazardous by the World Health Organization (WHO), and are expected to be useful for the development of novel drugs to treat infectious diseases.
Scientific journal New Journal of Chemistry：「Anti-bacterial β-cyclodextrin derivatives inspired by the anti-microbial peptide polymyxin in order to better understand the role of single hydrophobic chain tail in selective anti-bacterial activity」