A Research Paper from the Yamamura/Miyagawa Laboratory Published in the Journal of Polymer Science Selected as Cover Art
Category：News｜Publishing : April 5, 2023
A research paper titled "Synthesis of antimicrobial polymers with mannose residues as binders for the FimH adhesin of Escherichia coli" from the Yamamura/Miyagawa laboratory [authored by Atsushi Miyagawa (Associate Professor), Shinya Ohno (then, Master's Course student), and Hatsuo Yamamura (Professor)], published in the scientific journal Journal of Polymer Science, was highly evaluated and selected as cover art for the Journal of Polymer Science (Volume 61, Issue 4, February 15, 2023).
In this study, they were involved in research on antimicrobial polymers, a new series of antimicrobial substances. By polymerizing antimicrobial monomers with mannose, a monosaccharide, to synthesize antimicrobial polymers, they developed a method to impart not only antimicrobial properties but also bacterial selectivity. Since mannose binds to proteins in the pilus of Escherichia coli (E. coli), these antimicrobial polymers selectively bound to E. coli and exhibited antimicrobial properties. It was also confirmed that these antimicrobial polymers did not produce antimicrobial resistant bacteria after 15 passages. It is expected that this method will be used to advance the development of molecules that can selectively kill specific bacteria.
Journal of Polymer Science：Journal of Polymer Science：「Synthesis of antimicrobial polymers with mannose residues as binders for the FimH adhesin of Escherichia coli」